Under the DSCSA, all prescription drug transactions require documentation that identifies both the drug and its previous handlers. This includes Transaction Information (TI), and Transaction Statements (TS) — collectively known as "two (2) T's." Wholesalers and distributors need robust systems to document and store this data accurately, sharing it with partners downstream.)

A crucial aspect of DSCSA compliance is maintaining protocols to verify that prescription drugs are legitimate and fit for distribution. Verification involves checking product identifiers such as the National Drug Code (NDC), lot number, and expiration date. Additionally, having the ability to respond to verification requests from authorities within a specific time frame is essential for compliance.

To ensure traceability, all transaction records must be retained for a
minimum of six years. Effective recordkeeping not only assists in regulatory inspections but also supports operational transparency and traceability, making it easier to manage recalls and investigations swiftly.